Methods and compositions for panic disorders

摘要

Methods and compositions that down regulate the activity of orexins to treat panic disorder and panic-like responses associated with hypercapnic conditions are disclosed.

主权项

1. A method for treating a hypercapnia symptom in a subject in need thereof, the method comprising: administering to the subject in need thereof a small interfering RNA (siRNA) capable of reducing expression of orexin, wherein the subject in need thereof suffers from one or more hypercapnia symptoms selected from the group consisting of hypertension, anxiety, elevated sympathetic nervous system activity, and elevated respiration.