| 发明名称 |
ALK7:ACTRIIB HETEROMULTIMERS AND USES THEREOF |
| 摘要 |
In certain aspects, the disclosure provides soluble heteromeric polypeptide complexes comprising an extracellular domain of an ALK7 receptor and an extracellular domain of ActRIIB In certain aspects, these ALK7:ActRIIB heteromultimers are can be used to improve metabolic parameters in a patient in need thereof. In certain aspects, these ALK7:ActRIIB heteromultimers are can be used to treat or prevent one or more kidney-associated disease or condition in a patient in need thereof. |
| 申请公布号 |
US2016297867(A1) |
申请公布日期 |
2016.10.13 |
| 申请号 |
US201615092577 |
申请日期 |
2016.04.06 |
| 申请人 |
Acceleron Pharma Inc. |
发明人 |
Kumar Ravindra;Grinberg Asya;Sako Dianne;Pearsall Robert Scott;Castonguay Roselyne;Li Gang;Dagon Yossi |
| 分类号 |
C07K14/71;A61K38/17 |
主分类号 |
C07K14/71 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A recombinant heteromultimer comprising an ALK7 polypeptide and an ActRIIB polypeptide. |
| 地址 |
Cambridge MA US |
