IMIDAZO-FUSED HETEROCYCLES AND USES THEREOF

摘要

Compounds and methods in the fields of chemistry and medicine are disclosed. Some of the disclosed embodiments include compounds, compositions and methods of using imidazole-fused heterocycle amines. Some of the disclosed embodiments include imizazo-fused heterocycle compounds useful to treat leukemia and other hematopoietic disorders.

主权项

1. A compound of Formula I: or a pharmaceutically acceptable salt, ester, amide, or prodrug thereof, wherein X is selected from N or CR4a; X′ is selected from N or CR4b; Y is selected from N or CR5a; Y′ is selected from N or CR5b; provided at least one of X, X′, Y, and Y′ is N; R1 is selected from the group consisting of hydrogen, halogen, —OR6, —CN, —NR7R8, —CH2OR6, —CH2NR7R8, an optionally substituted C1-6 alkyl, an optionally substituted C1-6 haloalkyl, an optionally substituted C2-6 alkenyl, an optionally substituted C2-6 alkynyl, an optionally substituted (5 to 7 membered heterocyclyl)alkyl, an optionally substituted 5 to 7 membered heterocyclyl, an optionally substituted aralkyl; an optionally substituted (5 or 6 membered heteroaryl)alkyl, an optionally substituted C1-6 heteroalkyl, —C(═O)R6, —C(═O)OR6, —C(═O)NR7R8, —NHC(═O)R6, —SO2R6, and —SO2NR7R8; each of R2, R3, R4a and R4b is independently selected from the group consisting of hydrogen, halogen, C1-6 alkyl, OH, and C1-6 alkoxy; each of R5a and R5b is independently selected from the group consisting of hydrogen, halogen, —OR6, —CN, —NR7R8, —CH2OR6, an optionally substituted aryl, an optionally substituted 5 to 10 membered heteroaryl, an optionally substituted 5-10 membered heterocyclyl, an optionally substituted C3-7 carbocyclyl, an optionally substituted C1-6 alkyl, an optionally substituted C1-6 haloalkyl, an optionally substituted C1-6 heteroalkyl, —C(═O)R6, —C(═O)OR6, —C(═O)NR7R8, —NHC(═O)R6, —SO2R6, and —SO2NR7R8; each R6 is independently selected from hydrogen, an optionally substituted C1-10 alkyl, an optionally substituted C1-10 haloalkyl, or an optionally substituted C1-6 heteroalkyl; and each R7 and R8 is independently selected from hydrogen; an optionally substituted C1-10 alkyl; an optionally substituted C1-10 haloalkyl; or an optionally substituted C1-6 heteroalkyl; or R7 and R8 are joined together with the nitrogen atom to which they are attached to form an optionally substituted C3-7 cycloalkyl or 3 to 7 membered heterocyclyl ring.