Reinforced vascular protheses

摘要

Vascular grafts for treating, reconstructing and replacing damaged or diseased cardiovascular vessels that are formed from decellularized extracellular matrix (ECM). The vascular grafts include outer or outer and inner coatings that provide structural reinforcement.

主权项

1. A vascular graft for treating damaged or diseased tissue in cardiovascular vessels, comprising:
a biodegradable and remodelable tubular member comprising an extracellular matrix (ECM) composition comprising acellular ECM from a mammalian tissue source and an ECM-mimicking biomaterial comprising poly(glycerol sebacate) (PGS), said tubular member comprising an outer surface and a lumen that extends therethrough, said lumen defining a tubular member inner surface, said tubular member further comprising at least one biodegradable coating disposed on said tubular member outer surface, said tubular member being configured to induce modulated healing when disposed proximate damaged cardiovascular tissue, said modulated healing comprising modulation of inflammation of said damaged tissue, and induced host tissue proliferation, bioremodeling of said damaged tissue, and regeneration of new cardiovascular tissue and tissue structures with site specific structural and functional properties.