Drug eluting composite

摘要

The present invention relates to materials having therapeutic compositions releasably contained within the materials. The materials are configured to release therapeutic compositions at a desired rate. The present invention also relates to devices incorporating the materials.

主权项

1. A method for designing a therapeutic-releasing construction comprising:
providing a polymeric material that comprises a therapeutic composition, wherein the polymeric material is surrounded by an impermeable capping layer; determining a desired elution rate; designing said therapeutic-releasing construction comprising said polymeric material and a plurality of biocompatible polymeric barriers that define an elution pathway within said polymeric material, wherein the designing comprises configuring said elution pathway within the polymeric material to deliver the therapeutic composition from a starting position within the polymeric material to a release point in the polymeric material, the plurality of biocompatible polymeric barriers having a height such that each of said plurality of biocompatible polymeric barriers extends a full vertical distance between an inner surface and the outer surface of the polymeric material, and the elution pathway being configured structurally using said plurality of biocompatible polymeric barriers within the polymeric material to alter one or more of geometry, tortuosity, diffusion length, diffusion coefficient, and void volume of the elution pathway; predicting an elution rate of the therapeutic-releasing construction based on the geometry, the tortuosity, the diffusion length, the diffusion coefficient, and the void volume of the elution pathway; and verifying that said therapeutic-releasing construction will deliver said therapeutic composition according to said desired elution rate based on the designing of said therapeutic-releasing construction and said predicting of said elution rate.