Method for preparing 1-(4-(4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yi)prop-2-en-1-one

摘要

The present invention relates to a novel method for preparing 1-(4-(4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)prop-2-en-1-one in a simpler process as compared with conventional methods by allowing 4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-ol to react with an N-acyl piperidine derivative in an inert polar protic solvent in the presence of a base.

主权项

1. A method for preparing the compound of formula (I), which comprises the step of allowing the compound of formula (II) to react with the compound of formula (III) in an inert polar protic solvent in the presence of a base: wherein X is tosyloxy (OTs), mesyloxy (OMs), trifluoromethane sulfonate, fluorosulfonate or halogen; and Y is ethenyl or halogenoethyl.