Diphenylpiperazine derivative and drug for circulatory organ containing the same

摘要

PCT No. PCT/JP91/01227 Sec. 371 Date May 10, 1993 Sec. 102(e) Date May 10, 1993 PCT Filed Sep. 13, 1991 PCT Pub. No. WO92/05165 PCT Pub. Date Apr. 2, 1992.A diphenylpiperazine derivative represented by general formula (1), salt thereof, and drug for the circulatory organs containing the same as the active ingredient: <IMAGE> (1) ZCnH2nAr wherein R1 and R2 may be the same or different from each other and each represents hydrogen, halogen, alkyl, alkoxy, nitro, amino, hydroxy, optionally esterified carboxyl or trifluoromethyl; R3 represents hydrogen, alkyl, aralkyl, acyl, nitro or optionally esterified carboxymethyl; Ar represents phenyl or naphthyl which may have one to three substituents such as halogen, alkyl, alkoxy, aryloxy, aralkyloxy, nitro, amino, cyano, acyl, hydroxy, optionally esterified carboxyl, substituted sulfonyl, aryl or trifluoromethyl; Z represents sulfur or -NR4- wherein R4 represents hydrogen, alkyl, aralkyl, acyl, aryl, substituted sulfonyl or optionally esterified carboxyl; m represents a number of 1 to 5; and n represents a number of 0 to 5.