发明名称 |
Biosynthetic binding proteins for immunotargeting |
摘要 |
Disclosed is a formulation for targeting an epitope on an antigen expressed in a mammal. The formulation comprises a pharmaceutically acceptable carrier together with a dimeric biosynthetic construct for binding at least one preselected antigen. The biosynthetic construct contains two polypeptide chains, each of which define single-chain Fv (sFv) binding proteins and have C-terminal tails that facilitate the crosslinking of two sFv polypeptides. The resulting dimeric constructs have a conformation permitting binding of a preselected antigen by the binding site of each polypeptide chain when administered to a mammal. The formulation has particular utility in in vivo imaging and drug targeting experiments.
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申请公布号 |
US5753204(A) |
申请公布日期 |
1998.05.19 |
申请号 |
US19950461838 |
申请日期 |
1995.06.05 |
申请人 |
CHIRON CORPORATION;CREATIVE BIOMOLECULES, INC. |
发明人 |
HUSTON, JAMES S.;HOUSTON, L. L.;RING, DAVID B.;OPPERMANN, HERMANN |
分类号 |
C12N15/09;A61K39/395;A61K49/00;A61K51/00;A61K51/08;A61P35/00;C07H21/04;C07K16/22;C07K16/28;C07K16/30;C07K16/32;C07K16/46;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/13;C12N15/62;C12N15/66;C12P21/02;C12P21/08;C12R1/19;(IPC1-7):A61K49/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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