| 发明名称 |
METHOD FOR THE DIAGNOSIS AND PROGNOSIS OF CANCER |
| 摘要 |
The present invention provides methods and materials for diagnosing cancer in an individual using a tissue, blood or urine sample from the patient. Specifically, the disclosed method comprises determining the level of one or more metabolite selected from the group consisting of creatine riboside, metabolite 561+, Cortisol sulfate and N-acetylneuraminic acid. The present invention also provides a method for determining the prognosis of a cancer patient by determining the level of one or more metabolite selected from the group consisting of creatine riboside, metabolite 561+, Cortisol sulfate and N-acetylneuraminic acid. Also provided are kits for detecting cancer or determining the prognosis of a cancer patient. |
| 申请公布号 |
US2016169899(A1) |
申请公布日期 |
2016.06.16 |
| 申请号 |
US201414903706 |
申请日期 |
2014.07.11 |
| 申请人 |
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES |
发明人 |
HAZNADAR Majda;MATHE Ewy;PATTERSON Andrew D.;HARRIS Curtis Craig;GONZALEZ Frank;KRAUSZ Kristopher;MANN Soumen |
| 分类号 |
G01N33/574 |
主分类号 |
G01N33/574 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for detecting the presence of cancer, the method comprising a determining step selected from the group consisting of:
a) determining the level of at least two compounds selected from the group consisting of creatine riboside, metabolite 561+, cortisol sulfate and N-acetylneuraminic acid in a sample obtained from an individual; and, b) determining the level of one or more compounds selected from the group consisting of creatine riboside and metabolite 561+, in a sample from an individual;
wherein elevated levels of the at least two compounds in step a), or elevated levels of creatine riboside and/or metabolite 561+ in step b) indicates the presence of cancer. |
| 地址 |
Rockville MD US |
