Humanized IL-6 and IL-6 receptor

摘要

Mice that comprise a replacement of endogenous mouse IL-6 and/or IL-6 receptor genes are described, and methods for making and using the mice. Mice comprising a replacement at an endogenous IL-6Rα locus of mouse ectodomain-encoding sequence with human ectodomain-encoding sequence is provided. Mice comprising a human IL-6 gene under control of mouse IL-6 regulatory elements is also provided, including mice that have a replacement of mouse IL-6-encoding sequence with human IL-6-encoding sequence at an endogenous mouse IL-6 locus.

主权项

1. A genetically modified rodent animal whose genome comprises a replacement at an endogenous rodent IL-6 locus of a rodent gene encoding IL-6 with a human gene encoding human IL-6, wherein the human gene encoding human IL-6 is under control of endogenous rodent regulatory elements at the endogenous rodent IL-6 locus, wherein the rodent animal expresses human IL-6 and the replaced rodent gene encoding IL-6 is not expressed, and wherein the rodent animal comprises a normal B cell population compared to a wild type rodent animal of the same species and wherein the rodent is a rat or a mouse.