PARTIAL SKULL REPLACEMENTS CAPABLE OF MONITORING IN REAL TIME AND DELIVERING SUBSTANCES INTO BRAIN TISSUE, AND USES THEREOF

摘要

The present invention relates to a partial skull replacement consisting of polydimethylsiloxane (PDMS) and a method of monitoring biological tissues within a skull using the partial skull replacement. The method of monitoring using the partial skull replacement of the present invention has a minimal influence on intracranial pressure and cerebrospinal fluid flow as compared to a conventional cranial window technique using glass, and, by way of visualizing biological tissues within a skull with enhanced clarity, is expected to be usefully employed as a method of monitoring biological tissues within the skull.

主权项

1. A method of preparing a window in a skull, the method including:
removing the skull in a target site; and disposing a partial skull replacement consisting of polydimethylsiloxane (PDMS) in an area from which the skull was removed.