| 发明名称 |
CELL |
| 摘要 |
The present invention provides a cell which co-expresses a first chimeric antigen receptor (CAR) and second CAR at the cell surface, each CAR comprising: (i) an antigen-binding domain; (ii) a spacer (iii) a trans-membrane domain; and (iv) an endodomain wherein the antigen binding domains of the first and second CARs bind to different antigens, and wherein one of the first or second CARs is an activating CAR comprising an activating endodomain and the other CAR is an inhibitory CAR comprising a ligation-off inhibitory endodomain. |
| 申请公布号 |
US2016289293(A1) |
申请公布日期 |
2016.10.06 |
| 申请号 |
US201415037405 |
申请日期 |
2014.11.21 |
| 申请人 |
UCL BUSINESS PLC |
发明人 |
Pulé Martin;Kong Khai;Cordoba Shaun |
| 分类号 |
C07K14/705;C12N15/86;A61K35/17;C12N5/0783 |
主分类号 |
C07K14/705 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A T cell or natural killer (NK) cell which co-expresses a first chimeric antigen receptor (CAR) and second CAR at the cell surface, each CAR comprising:
(i) an antigen-binding domain; (ii) a spacer (iii) a trans-membrane domain; and (iv) an endodomainwherein the antigen binding domains of the first and second CARs bind to different antigens, and wherein one of the first or second CARs is an activating CAR comprising an activating endodomain and the other CAR is an inhibitory CAR comprising a ligation-on inhibitory endodomain. |
| 地址 |
London GB |
