| 摘要 |
The present invention relates to a novel family of protein kinase inhibitors, more specifically the present invention is directed to inhibitors of the members of the Tec or Src protein kinase families. The present invention also relates to the processes of preparation of these compounds, their intermediates, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative, inflammatory, autoimmune, or infectious diseases, disorders, or conditions in which protein kinase activity is implicated. |
| 主权项 |
1. A compound of Formula I: or pharmaceutically acceptable salt, solvate, solvate of salt, stereoisomer, tautomer, isotope, prodrug, complex or biologically active metabolite thereof, wherein R is selected from the group consisting of:
1) hydrogen,2) alkyl,3) heteroalkyl,4) carbocyclyl,5) heterocyclyl,6) aryl, or7) heteroaryl, wherein the alkyl, heteroalkyl, carbocyclyl, heterocycyl, aryl, or heteroaryl are optionally substituted; R1 is selected from the group consisting of:
1) hydrogen,2) alkyl,3) heteroalkyl,4) carbocyclyl,5) heterocyclyl, or6) halogen, wherein the alkyl, heteroalkyl, carbocyclyl, or heterocyclyl are optionally substituted; Y is E is oxygen; Z is W is selected from:
1) —OCH2R2, or2) —CH2OR2, wherein Y-E-Z-W is R2 is selected from substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl; X1 and X2 are independently selected from hydrogen or halogen; m is an integer from 0 to 4, or m′ is an integer from 0 to 4. |
