COMPUTATIONALLY OPTIMIZED BROADLY REACTIVE ANTIGENS FOR H1N1 INFLUENZA

摘要

PROBLEM TO BE SOLVED: To provide recombinant influenza hemagglutinin (HA) polypeptides.SOLUTION: Regarding the recombinant influenza HA polypeptides, influenza A H1N1 HA amino acid sequences have been downloaded from the NCBI Influenza Virus Resource database. H1N1 HA proteins from 1134 isolates from 1918-2011 have been used for generating consensus sequences, and 11 different consensus sequences have been generated which exhibit computationally optimized broad reactivity.SELECTED DRAWING: None