Method of securing an intralumenal frame assembly

摘要

A method is disclosed of enhancing the securing of an intralumenal frame assembly to intralumenal tissue at an in situ target location. The method can comprise delivering an intralumenal frame assembly mounted on a delivery device to a treatment location. The intralumenal frame can be deployed to expand in situ so that anchors on the intralumenal frame atraumatically grasp intralumenal tissue at the target location. A radially inward force can be exerted on the frame assembly to cause the proximal and distal anchors to grasp more forcefully the intralumenal tissue.

主权项

1. A method of delivering an intralumenal frame assembly to a native mitral valve, the native mitral valve having a native mitral valve annulus, the method comprising:
delivering the intralumenal frame assembly mounted on a delivery device to the native mitral valve while the intralumenal frame assembly is in a radially compacted state, wherein a tether at least partially encircles a portion of the intralumenal frame assembly during delivery, the tether configured to radially restrain a portion of the intralumenal frame assembly, the intralumenal frame assembly comprising:
a frame having a proximal end, a distal end and a middle portion and a longitudinal axis extending between the proximal and distal ends, the frame comprising a foreshortening portion comprising foreshortening cells, the foreshortening portion configured to be located within a plane of the native mitral valve annulus when the frame is expanded at the native mitral valve; anda plurality of proximal and distal anchors configured to atraumatically engage tissue on opposite sides of the native mitral valve annulus upon deployment of the intralumenal frame assembly; and deploying the intralumenal frame assembly so that the foreshortening portion of the frame expands within the plane of the native mitral valve annulus while the intralumenal frame assembly remains tethered with a first end and a second end of the tether extending proximally past the proximal end of the frame; wherein after the intralumenal frame assembly has been fully deployed at the native mitral valve, a diameter of the middle portion of the frame is greater than a diameter of the proximal end of the frame, the proximal anchors are located on a first side of the plane of the native mitral valve annulus and the distal anchors are located on a second side of the plane of the native mitral valve annulus.