发明名称 |
Engineered CRISPR-Cas9 nucleases with Altered PAM Specificity |
摘要 |
Engineered CRISPR-Cas9 nucleases with altered and improved PAM specificities and their use in genomic engineering, epigenomic engineering, and genome targeting. |
申请公布号 |
US2016319261(A1) |
申请公布日期 |
2016.11.03 |
申请号 |
US201615060448 |
申请日期 |
2016.03.03 |
申请人 |
The General Hospital Corporation |
发明人 |
Joung J. Keith;Kleinstiver Benjamin |
分类号 |
C12N9/22;C12N15/90 |
主分类号 |
C12N9/22 |
代理机构 |
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代理人 |
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主权项 |
1. An isolated Staphylococcus aureus Cas9 (SaCas9) protein with mutations at one or more of the following positions: E782, N968, and/or R1015. |
地址 |
Boston MA US |