| 发明名称 |
ACTIVIN-ACTRIIA ANTAGONISTS FOR INHIBITING GERM CELL MATURATION |
| 摘要 |
In certain aspects, the present invention provides compositions and methods for decreasing FSH levels in a patient. The patient may, for example, be diagnosed with an FSH-related disorder or desire to delay or inhibit germ cell maturation. |
| 申请公布号 |
US2016319254(A1) |
申请公布日期 |
2016.11.03 |
| 申请号 |
US201615148061 |
申请日期 |
2016.05.06 |
| 申请人 |
Acceleron Pharma Inc. |
发明人 |
Knopf John;Seehra Jasbir;Sherman Matthew L. |
| 分类号 |
C12N9/12 |
主分类号 |
C12N9/12 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for inhibiting FSH production in a patient desiring to delay or inhibit his or her germ cell maturation, the method comprising administering an amount of ActRIIa-Fc fusion protein effective to reduce FSH activity in the subject, wherein the ActRIIa-Fc fusion protein comprises an amino acid sequence that is at least 90% identical to the amino acid sequence of SEQ ID NO:3. |
| 地址 |
Cambridge MA US |
