Synergistic microbicidal combinations

摘要

Antimicrobial compositions based on the synergistic combination of 2-methyl-3-isothiazolone and selected commercial microbicides where the compositions are substantially free of halogenated 3-isothiazolone, are disclosed. Particularly preferred are combinations of 2-methyl-3-isothiazolone together with benzoic acid, citric acid, sorbic acid, 1,2-dibromo-2,4-dicyanobutane, 1,3-dimethylol-5,5-dimethylhydantoin, phenoxyethanol, benzyl alcohol, zinc pyrithione or climbazole, that provide enhanced microbicidal efficacy at a combined active ingredient level lower than that of the combined individual 3-isothiazolone and commercial microbicide effective use levels.

主权项

1. A microbicidal composition consisting of 2-methyl-3-isothiazolone and 1,2-dibromo-2,4-dicyanobutane which is effective for inhibiting growth of a bacterial or a yeast microorganism, wherein the ratio of 2-methyl-3-isothiazolone to 1,2-dibromo-2,4-dicyanobutane is (a) from 1/0.4 to 1/0.7 and over such range the composition exhibits synergy for inhibiting growth of Candida albicans; (b) from 1/1.6 to 1/2 and over such range exhibits synergy for inhibiting growth of Staphylococcus aureus; or (c) from 1/10 to 1/20 and over such range exhibits synergy for inhibiting growth of Pseudomonas aeruginosa.