Phenylalkyl amine derivatives having anti-ischaemic activity.

摘要

The invention relates to composition having anti-ischamemic activity which comprise as an active component at least one compound of the formula <CHEM> wherein: -R1 and R2 independent of each other represent hydrogen, alkyl having 1-3 C-atoms, on the understanding that R1 and R2 are not both hydrogen, or wherein R1+R2 together form an alkylene group having 1-3 C-atoms which may be substituted with one or more alkyl groups having 1-3 C-atoms; -Z is methylene optionally substituted with one alkyl group having 1-3 C-atoms, or Z is ethylene of which one or both carbon atoms may be substituted with one alkyl group having 1-3 C-atoms; -R3 and R4 independent of each other represent hydrogen, alkyl having 1-10 C-atoms, alkenyl or alkynyl having 3-10 C-atoms, cycloalkyl having 3-8 C-atoms, cycloalkyl-alkyl having 3-8 ring atoms and 1-5 C-atoms in the alkyl group, phenylalkyl or heteroaryl-alkyl having 1-5 C-atoms in the alkyl group, phenylalkenyl, heteraryl-alkenyl, phenylalkynyl or heteroaryl-alkynyl group having 3-5 C-atoms in the alkenyl group or alkynyl group, which groups R3 and R4 may be substituted with a group (R6)p wherein R6 is halogen, hydroxy, alkyl or hydroxyalkyl having 1-5 C-atoms, alkoxy having 1-3 C-atoms, S-alkyl, S(O)-alkyl or S(O)2-alkyl having 1-3 C-atoms, amino, mono- or dialkylamino having 1-3 C-atoms per alkyl group, trifluoromethyl, trifluoromethoxy or cyano, and p has the value 0-3, on the understanding that R3 and R4 are not both hydrogen, or wherein R3+R4 together with the nitrogen atom form a saturated or unsaturated heterocyclic group of 5 or 6 ringatoms, which may contain a second hetero-atom from the group consisting of oxygen, sulphur and nitrogen, which ring may be substituted with phenylalkyl having 1-3 C-atoms in the alkyl group, or with a group (R6)p wherein R6 and p have the above-mentioned meanings, or which ring may be annelated with a phenyl group; -R5 is hydrogen, alkyl having 1-12 C-atoms, alkenyl or alkynyl having 3-12 C-atoms, cycloalkyl having 3-8 C-atoms, cycloalkyl-alkyl having 3-8 ring atoms and 1-5 C-atoms in the alkyl group, phenylalkyl or heteroaryl-alkyl having 1-5 C-atoms in the alkyl sub-group, phenylalkenyl, heteroaryl-alkenyl, phenylalkynyl or heteroaryl-alkynyl having 3-5 C-atoms in the alkenyl sub-group or alkynyl sub-group, which groups may be substituted with a group (R6)p, wherein R6 and p have the above-mentioned meaning, and which alkyl sub-groups, alkenyl sub-groups and alkynyl sub-groups may contain a group -O-, -S- or CO, or a pharmacologically acceptable salt thereof.