发明名称 |
A NOVEL B-LYMPHOMA CELL LINE AND ANTIGEN |
摘要 |
<p>This invention provides an IL-6 dependent B-cell lymphoma cell line designated DS-1 deposited with the American Type Culture Collection, wherein the cell line is reactive with a monoclonal antibody produced by a hybridoma cell line designated 10D2F6 deposited with the American Type Culture Collection. The invention also provides a purified antigen reactive with a monoclonal antibody produced by 10D2F6. The antigen also exists on DS-1. Also provided is a method of detecting the presence of an antigen-stimulated T-cell comprising detecting the presence of the antigen on a lymphocyte. In addition, the invention provides a method of detecting the presence of a neoplastic cell comprising detecting the presence of the antigen on a cell which is not a normal T-cell.</p> |
申请公布号 |
CA2142989(A1) |
申请公布日期 |
1994.03.03 |
申请号 |
CA19932142989 |
申请日期 |
1993.08.20 |
申请人 |
UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES (THE) |
发明人 |
BOCK, GLENN H.;NELSON, DAVID L.;KURMAN, CAROLE C.;FLEISHER, THOMAS A. |
分类号 |
G01N33/53;A61K38/00;C07K14/725;C07K16/28;C07K16/30;C12N5/09;C12N5/10;C12N15/09;C12P21/02;C12P21/08;G01N33/577;(IPC1-7):C12N15/12;C07H21/00;C07K17/00;C07K14/705;C12Q1/68;G01N33/574;C12Q1/00;C12N5/08;A61K47/48 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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