COMPOSITIONS AND METHODS FOR STIMULATING BONE GROWTH

摘要

Compounds of formulas (1) and (2), wherein the variables of X, Y and R' are herein defined in the specification, promote bone information and are thus useful in treating osteoporosis, bone fracture or deficiency, primary or secondary hyperparathyroidism, periodontal disease or defect, metastatic bone disease, osteolytic bone disease, post-plastic surgery, post-prosthetic joint surgery, and post-dental implantation. The figure shows the structure and activity of several compounds of the invention namely, nevastatin, lovastatin and pravastatin, as tested in the in vitro BMP-promoter based assay.