发明名称 |
METHODS OF TREATING SKIN CANCER USING COMPOSITIONS COMPRISING AN INHIBITOR OF ENDOTHELIN RECEPTOR B |
摘要 |
Described herein are results which show that an endothelin receptor antagonist, BQ788, increases pigmentation and significantly reduces the viability of 7 human melanoma cell lines in culture. Moreover, it is described herein that administration of BQ788 significantly slows melanoma tumor growth in nude mice, including a complete growth arrest in half of the mice treated systemically. Thus, inhibitors of endothelin receptor activity are described herein as beneficial for the treatment of cancer.
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申请公布号 |
PT1280552(E) |
申请公布日期 |
2007.11.23 |
申请号 |
PT20000946969T |
申请日期 |
2000.06.29 |
申请人 |
CALIFORNIA INSTITUTE OF TECHNOLOGY |
发明人 |
PAUL H. PATTERSON;RONIT LE COUTRE-LAHAV |
分类号 |
A61K38/06;A61K38/22;A61K47/48;A61P35/00 |
主分类号 |
A61K38/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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