NOVEL CLEAVED FRAGMENTS OF FIBRINOGEN

摘要

The invention provides novel alpha ECX cleavage fragments of fibrinogen and methods for detecting and purifying these fragments. The method of the invention also includes a diagnostic method for determining fibrinolytic states or atherogenesis in a mammal. Methods of treating disease characterized by fibrinogen metabolism are also disclosed. In addition, the invention also provides monospecific antibodies which are specifically reactive with alpha EC domain of fibrinogen. Also provided, are DNA and RNA molecules that encode alpha ECX cleavage fragments of fibrinogen. In addition, the present invention includes a vector and a host cell capable of expressing alpha ECX cleavage fragments of fibrinogen.