HUMAN MONOCLONAL ANTIBODY TO PD-1 (PROGRAMMED DEATH 1) AND METHOD FOR TREATING CANCER USING THE SAME ANTI-PD-1 ANTIBODY ALONE OR IN COMBINATION WITH OTHER IMMUNOTHERAPY

摘要

PROBLEM TO BE SOLVED: To provide isolated human monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to PD-1 (programmed death 1) with high affinity.

SOLUTION: The isolated human monoclonal antibodies cross-competing for binding to the PD-1 with a reference antibody containing a human heavy chain and a light chain variable regions composed of a specific amino acid sequence or binding portions thereof are provided. Methods for detecting the PD-1 are provided and various diseases including caner and infective diseases can be treated by preparing immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies. Furthermore, hyperproliferative diseases such as cancer can be treated by using a combination immunotherapy such as the combination of anti-CTLA-4 and anti-PD-1 antibodies. Adverse events related to treatment with each of the antibodies are altered.

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