Benzimidazole-imidazole derivatives

摘要

Inhibitors of HCV replication of formula I;
including stereochemically isomeric forms, and salts, solvates thereof, wherein R and R′ are, each independently, —CR1R2R3, aryl, heteroaryl or heteroC4-6cycloalkyl, whereby aryl and heteroaryl may optionally be substituted with 1 or 2 substituents selected from halo and methyl.
;The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use in HCV therapy.

主权项

1. A compound of formula I or a stereoisomeric form thereof, wherein: A is naphthylene, which is optionally substituted with 1, 2 or 3 substituents selected from halo and C1-3alkyl; R and R′ are, each independently, —CR1R2R3, aryl, heteroaryl or heteroC4-6cycloalkyl, whereby aryl and heteroaryl may optionally be substituted with 1 or 2 substituents selected from halo and methyl; and wherein R1 is hydrogen;
C1-4alkyl optionally substituted with methoxy or dimethylamino;phenyl optionally substituted with 1, 2 or 3 substituents independently selected from halo, C1-4alkoxy, and trifluoromethoxy;1,3-benzodioxolanyl;benzyl optionally substituted with 1, 2 or 3 substituents independently selected from halo and methoxy;C3-6cycloalkyl;heteroaryl;heteroC4-6cycloalkyl; orheteroarylmethyl; R2 is hydrogen, hydroxyl, amino, mono- or di-C1-4alkylamino, C1-4alkylcarbonylamino, C1-4alkyloxycarbonylamino, C1-4alkylaminocarbonylamino, piperidin-1-yl or imidazol-1-yl; R3 is hydrogen, or R1 and R3 together form a cyclopropyl group; or R2 and R3 form oxo; or a pharmaceutically acceptable salt or a solvate thereof; wherein the compound is not