Vascularized porous metal orthopaedic implant devices

摘要

An osteoconductive vascularized porous metal implant device and method for implanting the vascularized device are described herein. The vascularized implant device comprises an implant which is porous titanium, tantalum or other metal which is biocompatible with the mammalian body and at least one vascular conduit which connects the porous implant to an animal vasculature, such as a human vascular system.

主权项

1. A vascularization device which is configured to increase blood circulation to a porous metal implant to effect an increase in bone growth internal to the device after implantation into a host, the device comprising:
the porous metal implant, which is biocompatible with the mammalian body, and is configured to provide structural rigidity between adjacent bone portions at the time of implantation, the metal of the implant selected from the group consisting of porous titanium, porous titanium-alloy, porous tantalum, porous tantalum-alloy, and combinations thereof, the metal implant having pores of about 300 nm depth and breadth, the porous metal implant being configured to provide a ratio of bone interface surface area to implant interface surface area which is less than about 0.75 after implantation; at least one implantable inlet vascular conduit comprising a biocompatible polymer and which is arranged and configured to supply blood into the implant and to connect the porous implant to a mammalian vascular system when the device is implanted, the at least one implantable inlet vascular conduit comprising a tube having a diameter in the range of from about 3 mm to about 9 mm, the biocompatible polymer comprising polytetrafluoroethylene; and at least one implantable outlet vascular conduit comprising a biocompatible polymer and which is configured to couple the implant to a second portion of the vascular system and transmit blood from the implant to the second portion of the vascular system after implantation, the at least one implantable outlet vascular conduit comprising a tube having a diameter in the range from about 3 mm to about 9 mm, the biocompatible polymer comprising polytetrafluoroethylene, the porous metal implant having a rigid structure with internal voids throughout an interior portion of the porous metal implant, and the internal voids forming at least 50% by volume of the implant, the porous metal implant configured to permit at least one of blood flow and bone growth into the internal voids, and the implantable inlet and the outlet vascular conduits and the porous metal implant configured and arranged to provide blood flow into and from the porous metal implant after implantation, the at least one implantable inlet vascular conduit extending within the porous metal implant and below an outer surface of the porous metal implant and configured to effect blood flow below the outer surface of the porous metal implant and outwardly to a periphery of the porous metal implant after implantation, wherein the at least one implantable inlet vascular conduit and the at least one implantable outlet vascular conduit include at least one attachment selected from the group consisting of a gasket, O-ring, stitching, staples, glue, and combinations thereof, wherein the attachment is configured to attach the at least one implantable inlet vascular conduit and the at least one outlet vascular conduit to the mammalian vascular system.