摘要 |
Genetically modified mice comprising a nucleic acid sequence encoding a human M-CSF protein are provided. Also provided are genetically modified mice comprising a nucleic acid sequence encoding a human M-CSF protein that have been engrafted with human cells such as human hematopoietic cells, and methods for making such engrafted mice. These mice find use in a number of applications, such as in modeling human immune disease and pathogen infection; inin vivoscreens for agents that modulate hematopoietic cell development and/or activity, e.g. in a healthy or a diseased state; in in vivoscreens for agents that are toxic to hematopoietic cells; in in vivoscreens for agents that prevent against, mitigate, or reverse the toxic effects of toxic agents on hematopoietic cells; in in vivo screens of human hematopoietic cells from an individual to predict the responsiveness of an individual to a disease therapy, etc. |
申请人 |
Regeneron Pharmaceuticals, Inc.;Institute for Research in Biomedicine (IRB);Yale University |
发明人 |
Murphy, Andrew J.;Stevens, Sean;Yancopoulos, George D.;Eynon, Elizabeth;Flavell, Richard;Rathinam, Chozhavendan;Manz, Markus |