发明名称 |
Method for the preparation of erythro vicinyl amino-alcohols |
摘要 |
The present invention is concerned with the preparation of erythro N-substituted vicinal aminoalcohol derivatives from hydroxyl-protected cyanohydrin derivatives by successive Grignard reaction, transimination using a primary amine, reduction of the resulting imine and removal of the hydroxyl-protecting group. The products are obtained either as a racemate or in an optically pure form, depending upon the stereochemical composition of the cyanohydrin derivatives.
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申请公布号 |
USRE35128(E) |
申请公布日期 |
1995.12.19 |
申请号 |
US19940255954 |
申请日期 |
1994.06.07 |
申请人 |
DUPHAR INTERNATIONAL RESEARCH B.V. |
发明人 |
BRUSSEE, JOHANNES;VAN DER GEN, ARNE;KRUSE, CORNELIS G. |
分类号 |
C07F7/18;C07B53/00;C07C213/00;C07C213/02;C07C215/30;C07C215/52;C07C215/60;(IPC1-7):C07C209/52 |
主分类号 |
C07F7/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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