发明名称 |
Method for creating specific, high affinity nuclear receptor pharmaceuticals |
摘要 |
This invention pertains to agonists that activate nuclear receptors. These agonists include an extension that contacts a region of the nuclear receptor outside the native ligand binding pocket. Methods for producing, identifying and designing such agonists are included along with nuclear receptor agonist complexes and libraries of agonists.
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申请公布号 |
US7302347(B2) |
申请公布日期 |
2007.11.27 |
申请号 |
US20020317034 |
申请日期 |
2002.12.10 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
BAXTER JOHN D.;SCANLAN THOMAS S.;FETTERICK ROBERT J.;BORNGRAEBER SABINE;WEBB PAUL |
分类号 |
G01N33/53;G01N33/68;G06G7/48 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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