发明名称 |
METHODS AND COMPOSITIONS FOR TREATING MALIGNANT TUMORS ASSOCIATED WITH KRAS MUTATION |
摘要 |
This invention provides methods and compositions for preventing, treating or ameliorating one or more symptoms of a malignant tumor associated with KRAS mutation in a mammal in need thereof, by identifying a tumor cell in the mammal, the tumor cell comprising at least one of: (i) a mutation of the KRAS gene, and (ii) an aberrant expression level of KRAS protein; and administering to the mammal a therapeutically effective amount of a composition comprising one or more RNAi molecules that are active in reducing expression of GST-π. |
申请公布号 |
WO2016106404(A3) |
申请公布日期 |
2016.09.15 |
申请号 |
WO2015US67559 |
申请日期 |
2015.12.28 |
申请人 |
NITTO DENKO CORPORATION;YING, Wenbin |
发明人 |
YING, Wenbin;MINOMI, Kenjirou;MAJETI, Bharat;WANG, Li;LIU, Jihua;ADAMI, Roger |
分类号 |
A61K31/52;A61K31/7088;A61K31/7105;A61K31/711;A61K31/713;A61K38/45 |
主分类号 |
A61K31/52 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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