METHOD FOR CREATING EQUATION FOR COMPUTING PROGNOSIS IN LUNG ADENOCARCINOMA USING IMMUNE FACTORS AS INDEXES, AND METHOD FOR PREDICTING PROGNOSIS THEREIN

摘要

Provided are a method for more easily and quickly predicting the prognosis in lung adenocarcinoma, and a method for creating a computing equation for embodying the aforesaid method. The method according to the present invention for creating an equation for computing prognosis is characterized by comprising: detecting the expression of PD-L1, Gal-9 and XAGE1 in specimens obtained from a plurality of lung adenocarcinoma patients using an immunostaining technique; on the basis of first data, said first data being obtained by binarizing a first score that is specified on the basis of the distribution range and expression intensity of PD-L1 of tumor in a tumor tissue, second data, said second data being obtained by binarizing a second score that is specified on the basis of the distribution range and expression intensity of Gal-9 of tumor in a tumor tissue, and third data, said third data being obtained by binarizing on the basis of the presence or absence of XAGE1 expression, dividing the lung adenocarcinoma patients into a good-prognosis cluster and a poor-prognosis cluster; and determining the computing equation for dividing the good-prognosis cluster and the poor-prognosis cluster by multivariate analysis using the first score, second score and third data as explanatory variables. The method according to the present invention for predicting the prognosis in lung adenocarcinoma is characterized by comprising substituting first and second scores and third data detected from a specimen of a subject into the computing equation determined above and predicting the prognosis of the subject by computation.