The present invention relates to isoforms of a human calcium sensing receptor, and to the genes encoding these isoforms. The invention further relates to methods of screening for agonists or antagonists of the isoforms, particularly with respect to calcium receptor activity, to diagnostic uses of these isoforms and to therapeutic uses of the agonists or antagonists. The invention also relates to gene therapy using the genes encoding the receptor isoforms or molecules capable of down-regulating receptor activity, such as antisense sequences.
申请公布号
WO0006601(A1)
申请公布日期
2000.02.10
申请号
WO1999US17116
申请日期
1999.07.28
申请人
AVENTIS PHARMACEUTICALS PRODUCTS INC.;YU, KIN, T.;LABAUDINIERE, RICHARD, F.;THROWER, LARRY, W.
发明人
YU, KIN, T.;LABAUDINIERE, RICHARD, F.;THROWER, LARRY, W.