| 摘要 |
The present invention is based upon the novel observation of the COX-II-specific inhibitory activity of gamma-tocopherol and that by combining gamma-tocopherol with precursors of connective tissue constituents, injured or degenerated connective tissue, especially of articulated joints of animal patients, may be repaired. The method of the invention for treating a inflammatory disorder of a joint comprises administering to the mammal a pharmaceutical composition comprising an amount of gamma-tocopherol effective in selectively inhibiting cyclooxygenase-2 and at least one compound that elevates the production of a component of connective tissue in an amount effective for the promotion of connective tissue formation. The invention also provides pharmaceutical or veterinary compositions comprising a tocopherol preparation having at least 50% w/w gamma- tocopherol or a derivative thereof and in an amount effective for selectively inhibiting cyclooxygenase-2 in the recipient mammal and at least one compound that elevates the production of a component of connective tissue. |
