发明名称 |
METHODS FOR MODULATING A DRUG-RELATED EFFECT OR BEHAVIOR |
摘要 |
The present invention provides a method of reducing or preventing a drug related effect or behavior in a subject by inhibiting N-type calcium channels. In addition, the invention provides a variety of prescreening and screening methods aimed at identifying agents that modulate a drug-related effect or behavior. These methods involve assaying test agent binding to N-type calcium channels or channel subunits. Alternatively, test agents can be screened for their ability to alter the level of N-type calcium channels, channel subunit polypeptide or RNA, or the depolarization-induced inward calcium current mediated by these channels. Finally, the invention also provides a diagnostic method that entails measuring one or more of these levels and determining risk for a drug-related effect or behavior based on comparison to the corresponding level for a control population. |
申请公布号 |
WO2005015159(A3) |
申请公布日期 |
2006.08.31 |
申请号 |
WO2004US25482 |
申请日期 |
2004.08.05 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA.;MESSING, ROBERT, O.;NEWTON, PHILIP, M. |
发明人 |
MESSING, ROBERT, O.;NEWTON, PHILIP, M. |
分类号 |
A61K38/00;A61K31/00;A61K31/455;A61K31/554;A61K38/16;A61K38/17;G01N33/68;G01N33/94 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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