VERWENDUNG VON EXTRAKTEN AUS PELARGONIUM-SPEZIES

摘要

The use of extracts or parts of Pelargonium species plants is claimed in the prophylaxis and/or treatment of disease-associated behavioral changes and/or chronic and/or post-viral fatigue syndrome, is new. - ACTIVITY - Immunomodulator; Antidepressant; CNS-Gen.; Eating-Disorders-Gen.; Muscular-Gen.; Hypnotic; Tranquilizer; Analgesic. - MECHANISM OF ACTION - None given. - A dry extract (I) of Pelargonium sidoides roots (obtained in 11% yield by macerating the roots twice with a 7-fold amount of 11 wt.% ethanol at 55 deg. C) was administered orally to mice, followed an hour later by intraperitoneal injection of lipopolysaccharide (LPS) at 400 micro g/kg. The mice were subjected to exploration behavioral tests for 3 minutes in a light-dark box. The average time spent in the light area was 83 seconds for vehicle-only controls, 134 seconds after treatment with LPS only, 119 seconds after treatment with LPS plus (I) at 100 mg/kg, 104 seconds after treatment with LPS plus (I) at 200 mg/kg and 97 seconds after treatment with LPS plus (I) at 100 mg/kg. (I) thus caused dose-dependent inhibition of LPS-induced behavioral changes.