| 发明名称 |
Antibody Conjugates |
| 摘要 |
Antibody/signal-generating moiety conjugates are disclosed that include an antibody covalently linked to a signal-generating moiety through a heterobifunctional polyalkyleneglycol linker. The disclosed conjugates show exceptional signal-generation in immunohistochemical and in situ hybridization assays on tissue sections and cytology samples. In one embodiment, enzyme-metallographic detection of nucleic acid sequences with hapten-labeled probes can be accomplished using the disclosed conjugates as a primary antibody without amplification. |
| 申请公布号 |
US2016187324(A1) |
申请公布日期 |
2016.06.30 |
| 申请号 |
US201615064792 |
申请日期 |
2016.03.09 |
| 申请人 |
Ventana Medical Systems, Inc. |
发明人 |
Bieniarz Christopher;Kosmeder Jerome W.;Lefever Mark;Kernag Casey A.;Ashworth-Sharpe Julia;Wong Jennifer |
| 分类号 |
G01N33/535;C12N9/16;C12N9/96;C07K16/44;A61K47/48 |
主分类号 |
G01N33/535 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An antibody-signal-generating moiety conjugate comprising an antibody covalently linked to a signal-generating moiety through a heterobifunctional PEG linker. |
| 地址 |
Tucson AZ US |
