COMPUESTOS DERIVADOS DE HETEROCICLOS DE NITROGENO FUSIONADOS; COMPOSICION FARMACEUTICA QUE COMPRENDE A DICHO COMPUESTO; Y USO DEL COMPUESTO PARA EL TRATAMIENTO DE LA OBESIDAD, SARCOPENIA, CAQUEXIA, ESPASMOS MUSCULARES, DEBILIDAD MUSCULAR DESPUES DE O

摘要

Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of obesity, sarcopenia, wasting syndrome, frailty, cachexia, muscle spasm, post-surgical and post-traumatic muscle weakness, neuromuscular disease, and other indications.