发明名称 forma cristalina de um inibidor de interação mdm2/4 e p53
摘要 A crystalline form of (S)-1-(4-Chloro-phenyl)-7-isopropoxy-6-methoxy-2-(4-{methyl-[4-(4-methyl-3-oxo-piperazin-1-yl)-trans-cyclohexylmethyl]-amino}-phenyl)-1,4-dihydro-2H-isoquinolin-3-one, which is useful in the treatment of a disease or disorder associated with the interaction between p53, or variants thereof, and MDM2 and/or MDM4, or variants thereof, respectively.
申请公布号 BR112013011966(A2) 申请公布日期 2016.08.30
申请号 BR20131111966 申请日期 2011.11.17
申请人 NOVARTIS AG 发明人 HAIXIA REN;JOERG BERGHAUSEN
分类号 A61K31/495;A61P35/00;C07D401/12 主分类号 A61K31/495
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