Interferon receptor 1 antibodies and their uses

摘要

The present invention provides isolated human monoclonal antibodies that bind to IFNAR-1 and that are capable of inhibiting the biological activity of Type I interferons. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting Type I interferon-mediated disorders using the antibodies of the invention, including methods for treating autoimmune disorders, transplant rejection or Graft Versus Host Disease using the antibodies of the invention.

主权项

1. An isolated monoclonal antibody, or antigen-binding portion thereof, which specifically binds to human interferon alpha receptor 1 (IFNAR-1), wherein the antibody or antigen-binding portion thereof is selected from the group consisting of:
(a) an antibody, or antigen-binding portion thereof, comprising: a heavy chain variable region CDR1 comprising the amino acid sequence of SEQ ID NO: 1; a heavy chain variable region CDR2 comprising the amino acid sequence of SEQ ID NO:5; a heavy chain variable region CDR3 comprising the amino acid sequence of SEQ ID NO:9; a light chain variable region CDR1 comprising the amino acid sequence of SEQ ID NO: 13; a light chain variable region CDR2 comprising the amino acid sequence of SEQ ID NO: 17; and a light chain variable region CDR3 comprising the amino acid sequence of SEQ ID NO:21; (b) an antibody, or antigen-binding portion thereof, comprising: a heavy chain variable region CDR1 comprising the amino acid sequence of SEQ ID NO:2; a heavy chain variable region CDR2 comprising the amino acid sequence of SEQ ID NO:6; a heavy chain variable region CDR3 comprising the amino acid sequence of SEQ ID NO: 10; a light chain variable region CDR1 comprising the amino acid sequence of SEQ ID NO: 14; a light chain variable region CDR2 comprising the amino acid sequence of SEQ ID NO: 18; and a light chain variable region CDR3 comprising the amino acid sequence of SEQ ID NO:22; and (c) an antibody, or antigen-binding portion thereof, comprising: a heavy chain variable region CDR1 comprising the amino acid sequence of SEQ ID NO:4; a heavy chain variable region CDR2 comprising the amino acid sequence of SEQ ID NO:8; a heavy chain variable region CDR3 comprising the amino acid sequence of SEQ ID NO: 12; a light chain variable region CDR1 comprising the amino acid sequence of SEQ ID NO: 16; a light chain variable region CDR2 comprising the amino acid sequence of SEQ ID NO:20; and a light chain variable region CDR3 comprising the amino acid sequence of SEQ ID NO:24.