Agents that engage antigen-presenting cells through dendritic cell asialoglycoprotein receptor (DC-ASGPR)

摘要

The present invention includes compositions and methods for making and using anti DC-ASGPR antibodies that can, e.g., activate DCs and other cells.

主权项

1. A method for increasing the effectiveness of antigen presentation by dendritic cells in an individual comprising the steps of:
attaching ex vivo a dendritic cell asialoglycoprotein receptor (DC-ASGPR)-specific antibody or DC-ASGPR-specific fragment thereof to an antigen to form an antibody-antigen complex, wherein the antigen is an autoantigen; and delivering an effective amount of the complex to the individual, wherein the antigen is processed and presented by a dendritic cell that has been contacted with the antibody-antigen complex, wherein the antibody or fragment thereof comprises an immunoglobulin heavy chain selected from the group consisting of SEQ ID NO: 5, 7, 9, or 11, wherein the antibody or fragment thereof targets a human DC-ASGPR.