| 发明名称 |
METHOD OF IMPROVING THE APPEARANCE OF SKIN AND COMPOSITIONS THEREFOR |
| 摘要 |
A cosmetic method for reducing the level of High-Mobility Group Protein B1 released from keratinocytes. The method includes identifying a target portion of skin where reduction of HMGB1 level is desired, and topically applying a nicotinamide riboside containing cosmetic composition to the target portion of skin during a treatment period, which is sufficient to reduce the level of HMGB1 released by keratinocytes. By reducing HMGB1 protein level, melanocyte dendricity can be reduced, thereby resulting in less melanin being taken into keratinocytes. The reduction in melanin transfer may provide a way to treat skin pigmentation disorders such as hyperpigmented spots. |
| 申请公布号 |
US2016317418(A1) |
申请公布日期 |
2016.11.03 |
| 申请号 |
US201615141976 |
申请日期 |
2016.04.29 |
| 申请人 |
The Procter & Gamble Company |
发明人 |
HAKAZAKI Tomohiro;LAUGHLIN, II Leo Timothy;OBLONG John Erich |
| 分类号 |
A61K8/60;A61K8/49;A61K8/02;A61Q19/02;A61K8/06 |
主分类号 |
A61K8/60 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A cosmetic method of reducing the level of High-Mobility Group Protein B1 (HMGB1) released from keratinocytes, comprising:
a. identifying a target portion of skin where reduction of HMGB1 level is desired; and b. topically applying a cosmetic composition to the target portion of skin during a treatment period, wherein the cosmetic composition comprises an effective amount of nicotinamide riboside, and the treatment period is sufficient to reduce the level of HMGB1 released by keratinocytes. |
| 地址 |
Cincinnati OH US |
