摘要 |
PURPOSE: Provided is cephachlor sustained-release tablet compositions for providing continuously a medical action by making a persistent granule containing a speedily soluble granule in a tablet and a preparation method thereof is provided. CONSTITUTION: A cephachlor sustained-release tablet composition comprises about 30 to 95 wt.% of cephachlor, 1 to 3 wt.% of water-soluble binder, 0.1 to 30 wt.% preferentially, 1 to 10 wt.% of sustained matrix substrate, and 0.1 to 14 wt.% of lubricant. The composition is characterized in that a speedily-solubled granule is released at early stage and persistent granule is released at the late stage, thereby, active ingredients are released at regular intervals through stomach and intestines. The releasing speed is controlled by the kind and the content of a binder at the early stage then by the content of a lubricant at the late stage.
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