发明名称 BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS
摘要 The present invention relates to compounds of general formula (I) wherein X is a single bond or an ethynediyl group, wherein, in case X is a single bond, R<1> is halogen or phenyl which is optionally substituted with halogen, lower alkyl, halo-lower alkyl, lower alkoxy, halo-lower alkoxy, or cyano; In case X is an ethynediyl group, R<1> is phenyl, optionally substituted with halogen, lower alkyl, halo-lower alkyl, lower cycloalkyl, lower alkoxy or halo-lower alkoxy; R<3> is a 5 or 6 membered aryl or heteroaryl which are optionally substituted. The compounds according to the present invention can be used for treating or preventing acute and/or chronic neurological disorders such as psychosis, schizophrenia, Alzheimer's disease, cognitive disorders and memory deficits.
申请公布号 WO0129011(A3) 申请公布日期 2001.11.08
申请号 WO2000EP09553 申请日期 2000.09.29
申请人 F. HOFFMANN-LA ROCHE AG 发明人 ADAM, GEO;ALANINE, ALEXANDER;GOETSCHI, ERWIN;MUTEL, VINCENT;WOLTERING, THOMAS, JOHANNES
分类号 A61K31/55;A61K31/551;A61K31/5513;A61P1/08;A61P3/08;A61P9/00;A61P9/10;A61P13/00;A61P21/02;A61P25/00;A61P25/04;A61P25/06;A61P25/14;A61P25/16;A61P25/18;A61P25/22;A61P25/24;A61P25/28;A61P25/34;A61P25/36;A61P27/02;A61P43/00;C07D243/12;C07D401/04;C07D401/06;C07D401/14;C07D403/10;C07D403/14;C07D405/04;C07D405/06;C07D409/04;C07D413/04;C07D413/10;C07D413/14;C07D417/04;C07D417/10;C07D417/14;C07D491/056;C07D491/113;C07F7/10;(IPC1-7):C07D243/12 主分类号 A61K31/55
代理机构 代理人
主权项
地址