Topical compositions comprising ascomycins

摘要

The present invention relates to a composition for topical administration comprising an ascomycin and a carrier vehicle comprising means to retain water in the outer skin layer and means to hinder water evaporating from the skin.

主权项

1. A composition for topical administration for treatment of skin disorders which composition comprises: 33-epi-chloro-33-desoxy-ascomycin and a carrier vehicle comprising
(i) a moisturizer consisting of a urea, an inorganic salt, and a carboxylic acid or a derivative thereof selected from the group consisting of glycolic acid, 2-pyrrolidone-5-carboxylate, salts thereof, and mixtures thereof; (ii) a component to hinder water evaporating from the skin consisting of at least one hydrocarbon; and (iii) a solvent selected from the group consisting of a lipophilic solvent, a polar solvent, and mixtures thereof; wherein 33-epi-chloro-33-desoxy-ascomycin is present in an amount of 0.1 to 2% by weight; wherein the moisturizer is present in an amount of 5 to 15%; wherein the at least one hydrocarbon is present in an amount of 75 to 90%; wherein the solvent is present in an amount of 2 to 10%; and wherein the composition is substantially water-free.