| 主权项 |
1. A compound of formula (I) wherein R1 is halogen, halophenyl, cycloalkylalkoxy, halophenylalkyl, oxetanyloxy, haloalkoxy, halophenylalkoxy or alkyloxetanylalkoxy; R2 is halogen, cycloalkyl, haloazetidinyl, halopyrrolidinyl, cycloalkenyl, halocycloalkyl or halooxetanyl; one of R3 and R4 is hydrogen or alkyl and the other one is —(CR5R6)—(CR7R8)n—R9; or R3 and R4 together with the nitrogen atom to which they are attached form 2-oxo-5-aza-spiro[3.4]octyl, haloazetidinyl or halopyrrolidinyl; R5 and R6 are independently selected from hydrogen, alkyl, cycloalkylalkyl, haloalkyl, cycloalkyl, alkylsulfonylalkyl, phenylalkoxyalkyl, hydroxyalkyl, haloazetidinylalkyl, haloazetidinylcarbonyl, 2-oxa-6-azaspiro[3,3]heptanylcarbonyl, alkylaminocarbonyl, di alkylaminocarbonyl, aminocarbonyl, azetidinylcarbonyl, oxetanyl alkyl and alkyl oxetanyl; or R5 and R6 together with the carbon atom to which they are attached form cycloalkyl, oxetanyl, oxanyl or dioxothietanyl; R7 and R8 are independently selected from hydrogen, alkyl and cycloalkyl; or R7 and R8 together with the carbon atom to which they are attached form cycloalkyl; R9 is alkyl, alkoxycarbonyl, hydroxyl, hydroxyalkyl, aminocarbonyl, cyano, pyridinyl, alkylaminocarbonyl, thiazol-2-yl, oxazol-2-yl, 5-alkyl-[1,2,4]oxadiazol-3-yl, alkyltetrazolyl, alkylthiazol-2-yl, 1H-tetrazolyl, 5-amino-[1,2,4]-oxadiazol-3-yl, 5-alkyl-[1,3,4]-oxadiazol-2-yl, azetidinylcarbonyl, haloazetidinylcarbonyl, 6-oxa-1-azaspiro[3.3]heptanyl, 5-phenyl-[1,3,4]-oxadiazol-2-yl or haloalkylaminocarbonyl; and n is 0 or 1; provided that when R3 and R4 are both alkyl at the same time, then R1 and R2 are not both halogen at the same time; or a pharmaceutically acceptable salt or ester thereof. |
