发明名称 |
Agomelatine sulfuric acid complex, and preparation method and application thereof |
摘要 |
The present invention relates to an Agomelatine sulfuric acid complex in formula (I) and the preparation method thereof (HX=H2SO4, RSO3H (R═CH3, Ph, 4-CH3Ph)). The solubility of the Agomelatine sulfuric acid complex obtained by the method of the present invention is significantly improved compared with Agomelatine, has good stability and higher purity, and is suitable for application in finished-product medicinal preparations. The preparation process is quite simple, and a product with high purity can be obtained without special operations.; |
申请公布号 |
US9409857(B2) |
申请公布日期 |
2016.08.09 |
申请号 |
US201314401419 |
申请日期 |
2013.05.14 |
申请人 |
SHANGHAI RIGHTHAND PHARMTECH, CO., LTD. |
发明人 |
Wang Haiping;Chi Cheng;Chi Zhengming;Wang Jin;Xu Guanyu |
分类号 |
C07C303/02;C07C309/04;C07C233/18;C07C309/29;C07C309/30 |
主分类号 |
C07C303/02 |
代理机构 |
Foley & Lardner LLP |
代理人 |
Meara Joseph;Foley & Lardner LLP |
主权项 |
1. An Agomelatine acid complex as in formula I: wherein HX is H2SO4 or CH3SO3H, and wherein the Agomelatine acid complex is a crystalline solid. |
地址 |
Shanghai CN |