发明名称 |
DNA POLYMERASES WITH INCREASED 3'-MISMATCH DISCRIMINATION |
摘要 |
Disclosed are mutant DNA polymerases having increased 3 '-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases. |
申请公布号 |
CA2801998(C) |
申请公布日期 |
2016.11.08 |
申请号 |
CA20112801998 |
申请日期 |
2011.06.17 |
申请人 |
F. HOFFMANN LA-ROCHE AG |
发明人 |
REICHERT, FRED L.;BAUER, KEITH A.;MYERS, THOMAS W.;SCHOENBRUNNER, NANCY J.;SAN FILIPPO, JOSEPH |
分类号 |
C12N9/12;C12N15/10;C12N15/54 |
主分类号 |
C12N9/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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