发明名称 |
PIPERIDINE/PIPERAZINE DERIVATIVES |
摘要 |
The invention relates to a DGAT inhibitor of formula (I) including any stereochemically isomeric form thereof, wherein A represents CH or N; X represents O or NRx; the dotted line represents an optional bond in case A represents a carbon atom; Y represents a direct bond; -NRx -C(=O)-; -C(=O)-NRx -; -NRx -C(=O)- Z-; -NRx -C(=O)-Z-NRy -; -NRx -C(=O)-Z-NRy -C(=O)-; -NRx -C(=O)-Z-NRy -C(=O)-O-; -NRx -C(=O)-Z-O-; -NRx -C(=O)-Z-O-C(=O)-; -NRx -C(=O)-Z-C(=O)-; -NRx -C(=O)-Z-C(=O)-O-; -NRx -C(=O)-O-Z-C(=O)-; -NRx -C(=O)-O-Z-C(=O)-O-; -NRx -C(=O)-O-Z- O-C(=O)-; -NRx -C(=O)-Z-C(=O)-NRy -; -NRx -C(=O)-Z-NRy -C(=O)-NRy -; -C(=O)-Z-; -C(=O)-Z-O-; -C(=O)-NRx -Z-; -C(=O)-NRx -Z-O-; -C(=O)-NRx -Z-C(=O)-O-; -C(=O)-NRx -Z-O-C(=O)-; -C(=O)-NRx -O-Z-; -C(=O)-NRx -Z-NRy -; -C(=O)-NRx -Z- NRy -C(=O)-; -C(=O)-NRx -Z-NRy -C(=O)-O-; R1 represents optionally substituted C1-12alkyl; C2-6alkenyl; C2-6alkynyl; C3-6cycloalkyl; aryl1; aryl1 C1-6alkyl; Het1; or Het1C1- 6alkyl; provided that when Y represents -NRx -C(=O)-Z-; -NRx -C(=O)-Z-NRy; -NRx - C(=O)-Z-C(=O)-NRy -; -C(=O)-Z-; -NRx -C(=O)-Z-NRy -C(=O)-NRy -; -C(=O)-NRx -Z-; -C(=O)-NRx -O-Z-; or -C(=O)-NRx -Z-NRy -; then R1 may also represent hydrogen; R2 and R3 each independently represent hydrogen; hydroxyl; carboxyl; halo; C1-6alkyl; polyhaloC1-6alkyl; C1-6alkyloxyoptionally substituted withC1-4alkyloxy; C1-6alkylthio; polyhaloC1-6alkyloxy; C1-6alkyloxycarbonyl; cyano; aminocarbonyl; mono-or di(C1-4alkyl)aminocarbonyl; C1-6alkylcarbonyl; nitro; amino; mono-or di(C1-4alkyl)amino; -S(=O) p-C1-4alkyl; R4 represents hydrogen; hydroxyl; carboxyl; halo; C1-6alkyl; polyhaloC1-6alkyl; optionally substituted C1-6alkyloxy; C1-6alkylthio; polyhalo-C1-6alkyloxy; C1-6alkyloxycarbonyl wherein C1-6alkyl mayoptionally be substituted; cyano; C1-6alkylcarbonyl; nitro; amino; mono-or di(C1-4alkyl)amino; C1-4alkylcarbonylamino; -S(=O) p-C1-4alkyl; R6 R5 N-C(=O)-; R6 R5 N-C1-6alkyl; C3-6cycloalkyl; aryl; aryloxy; arylC1-4alkyl; aryl-C(=O)-C1-4alkyl; aryl-C(=O)-; Het; HetC1-4alkyl; Het-C(=O)-C1-4alkyl; Het-C(=O)-; Het-O-; R9 represents hydrogen, halo,C1-4alkyl, C1-4alkyl substituted with hydroxyl; a N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use as a medicine of saidcompounds. |
申请公布号 |
CA2687918(C) |
申请公布日期 |
2016.11.08 |
申请号 |
CA20082687918 |
申请日期 |
2008.06.05 |
申请人 |
JANSSEN PHARMACEUTICA N.V. |
发明人 |
BONGARTZ, JEAN-PIERRE ANDRE MARC;VAN LOMMEN, GUY ROSALIA EUGEEN;COESEMANS, ERWIN;BUYCK, CHRISTOPHE FRANCIS ROBERT NESTOR |
分类号 |
C07D295/215;A61K31/495;A61K31/496;A61P3/00;A61P3/10 |
主分类号 |
C07D295/215 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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