发明名称 |
''método para a seleção de um clone de célula e para a produção de um polipeptídeo e kit'' |
摘要 |
Herein is reported a method for determining methylation of a promoter nucleic acid operably linked to a nucleic acid encoding a polypeptide and thereby determining the long-term productivity of a cell. Also an aspect is a method for selecting a cell for producing a polypeptide by determining the methylation of the promoter nucleic acid operably linked to the structural gene encoding the polypeptide. |
申请公布号 |
BR112012026176(A2) |
申请公布日期 |
2016.11.29 |
申请号 |
BR20121126176 |
申请日期 |
2011.04.13 |
申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
ANDREA OSTERLEHNER;SILKE SIMMETH;ULRICH GOEPFERT |
分类号 |
C07K16/00;C12P21/02;C12Q1/68 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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