发明名称 SUBSTITUTED PYRAZOLO[3,4-D]PYRIMIDINES AND USES THEREOF
摘要 Presented herein are novel therapeutic compounds and methods of using the same for the treatment of cancers.
申请公布号 US2016354377(A1) 申请公布日期 2016.12.08
申请号 US201615078657 申请日期 2016.03.23
申请人 The Regents of the University of California ;Icahn School of Medicine at Mount Sinai 发明人 Dar Arvin C.;Das Tirtha K.;Sos Martin;Bivona Trever G.;Shokat Kevan M.;Cagan Ross L.
分类号 A61K31/519;A61K45/06 主分类号 A61K31/519
代理机构 代理人
主权项 1. A method of treating cancer in a subject in need thereof, said method comprising administering to the subject an effective amount of a compound having the formula: wherein R1 and R2 are independently hydrogen or substituted or unsubstituted alkyl; R3 is independently substituted or unsubstituted alkyl; R5 is independently halogen, —CN, —CXa3, —S(O)2H, —NO, —NO2, —C(O)H, —C(O)NH2, —S(O)2NH2, —OH, —SH, —SO2Cl, —SO3H, —SO4H, —NHNH2, —ONH2, —NHC═(O)NHNH2, —NHC═(O)NH2, —NHSO2H, —NHC═(O)H, —NHC(O)—OH, —NHOH, —OCF3, —OCHF2, —CO2H, or substituted or unsubstituted (C1-C6) alkyl; R6 is independently halogen, —CN, —CXb3, —S(O)2H, —NO, —NO2, —C(O)H, —C(O)NH2, —S(O)2NH2, —OH, —SH, —SO2Cl, —SO3H, —SO4H, —NHNH2, —ONH2, —NHC═(O)NHNH2, —NHC═(O)NH2, —NHSO2H, —NHC═(O)H, —NHC(O)—OH, —NHOH, —OCF3, —OCHF2, or —CO2H; L1 is independently a bond or substituted or unsubstituted alkylene; z1 is independently an integer from 0 to 4; z2 is independently an integer from 0 to 5; and Xa and Xb are independently —F, —Cl, —Br, or —I.
地址 Oakland CA US